Serena is the latest big name to pull out of the tournament after reigning men's champion Thiem and four-time winner Nadal ended their 2021 season due to injuries
Serena Williams has withdrawn from next week's US Open after the American said Wednesday that her torn hamstring had not completely healed ahead of the final Grand Slam of the year.
Williams, a six-times winner at Flushing Meadows, has had an injury-marred season and limped out of her first-round match at Wimbledon in tears due to the leg injury.
The 39-year old, who has been on the hunt for an elusive 24th major, skipped the Olympics in Tokyo and also opted out of the Cincinnati Masters, a tune-up event to the US Open.
Williams confirmed this in a statement on Instagram.
Williams is the latest big name to pull out of the tournament after reigning men's champion Dominic Thiem and four-time winner Rafael Nadal ended their 2021 season due to injuries.
Her withdrawal from the tournament casts further doubt over whether she can match Margaret Court's record of 24 major titles, as she turns 40 next month.
Williams has reached the finals in four Grand Slams since giving birth to daughter Olympia four years ago but has not triumphed in a major since picking up her 23rd title at the 2017 Australian Open, losing in straight sets on each occasion.
Speaking to reporters on Tuesday, ESPN analyst and Hall of Famer Pam Shriver said she was uncertain whether Williams could break through, given the depth of talent in women's tennis.
The main draw of the US Open gets underway in New York Monday.