The exhibition event will take place on US soil for the first time this week when 12 of the world's top players square off against each other in a three-day team event in Chicago
The second instalment of the Laver Cup comes at just the right time for 14-time Grand Slam winner Novak Djokovic who is back in top form after winning the US Open.
Djokovic is making his debut in this week's three-day team event which has been dubbed the Ryder Cup of tennis although it lacks the tradition of golf's premier event.
"I would like to play with (Djokovic)," said event founder and Team Europe star Roger Federer. "I hope he feels the same way."
The exhibition event will take place on US soil for the first time this week when 12 of the world's top players square off against each other in a three-day team event in Chicago.
The tournament begins Friday and pits a team of six of the best ATP Tour players from Europe against a six players from the rest of the world.
Bjorn Borg's favoured Team Europe will try to defend their crown against Team World which will be captained by the legendary John McEnroe.
Federer, Djokovic, Alexander Zverev, Grigor Dimitrov, David Goffin and Kyle Edmund will play for Team Europe.
"We're here to defend our title," Borg said, "And we’re going to keep the cup in Europe."
Jack Sock, Nick Kyrgios, John Isner, Frances Tiafoe, Kevin Anderson and Diego Schwartzman are representing Team World.
McEnroe sees the partisan crowd as a key to Team World's success.
"I'm very much looking forward to coaching this team,” said McEnroe.
"We're excited about getting the home-court advantage, hopefully, in Chicago, which is a great sports town. I think we're looking forward to showcasing our talents this weekend.
"We have four of the six core guys from last year. We're hopeful that the crowd is as involved or more than they were last year.”
The inaugural tournament took place in Prague in September which Team Europe won 15-9.
The format calls for shorter matches. If the players split sets, they go straight to a 10-point tiebreaker.
200 trophies. 2 Grand Slams. 1 Laver Cup— Laver Cup (@LaverCup) September 15, 2018
Who will take home the silverware when Team Europe take on Team World in Chicago starting September 21? https://t.co/Kbgjh0FFs8 #LaverCup pic.twitter.com/HpxQ0r7kJd
The event marks a bit of a homecoming for the South African-born Anderson as the world No.9 spent two years at the University of Illinois.
"My wife's family is from just 20 minutes north of here," said Anderson.
Tiafoe was a late addition to Team World after Juan Martin del Potro pulled out following his stellar run to the final of the US Open.
The event is named in honour of tennis legend Rod Laver, who won a record 200 singles titles, 11 Grand Slams and five Davis Cups for Australia.
Relive the moment Roger Federer defeated Nick Kyrgios to claim the inaugural Laver Cup for Team Europe last year.— Sky Sports Tennis 🎾 (@SkySportsTennis) September 21, 2018
Watch the Laver Cup live on Sky Sports Action and Sky Sports Mix at 6.30pm pic.twitter.com/TcjfBf2wOD