On the eve of Wednesday's Champions League game at Borussia Moenchengladbach, Manchester City coach Pep Guardiola revealed captain Vincent Kompany could 'be out for weeks' with a knee injury.
City are chasing a win in Germany to put them in the last 16, but they must do so without their skipper.
Kompany, 30, went off with concussion during Saturday's Premier League win at Crystal Palace, but also has knee-ligament damage.
"Kompany has a problem with his knee. He could be out for weeks. He's sad and I'm sad," said Guardiola.
Kompany has had calf, groin and thigh injuries in 2016 and has started just two league matches this season.
City, second in Group C behind leaders Barcelona, will book their knock-out phase place with another victory over Gladbach having won the reverse fixture 4-0 when Sergio Aguero scored a hat-trick in mid-September.
The 28-year-old striker revels in clashes against German clubs.
He also scored on his last visit to Borussia Park in September 2015, converting a 90th-minute penalty to earn City a 2-1 win, and netted a hat-trick in a 3-2 victory at home to Bayern Munich in November 2014.
This is the first time Guardiola has returned to Germany for a competitive game since he quit Bayern Munich in May after winning seven titles in three seasons.
He rested Ilkay Gundogan against Palace and only used David Silva off the bench, a hint that both may feature at Borussia Park.
Even without Kompany, Guardiola has plenty of options as City look to build on their stunning 3-1 defeat of Barcelona three weeks ago.
"We were so happy with beating Barcelona, but it was just one game," said Guardiola, who dismissed notions City are amongst the favourites to win next June's final in Cardiff.
"We cannot be considered favourites to win.
"Maybe in ten years, but we need time to achieve that.
"Barca and Real Madrid are there every year.
"I am trying to do a lot in the next few years to be there."